THE RELATIONSHIP OF THE RATIO TAURINE/ALANINE IN SERUM AND INDICATORS OF HEART RATE VARIABILITY IN PATIENTS WITH POSTINFARCTION CARDIOSCLEROSIS AND DIABETES MELLITUS TYPE 2
Анотація
The aim of the article : to determine the relationship of the ratio taurine/alanine (Tau/Ala) serum indicators of heart rate variability (HRV) in patients with postinfarction cardiosclerosis (PICS) and diabetes mellitus type 2 (DM 2). Materials and methods: we examined 87 patients with PICS and DM 2 – 50 women and 37 men, median age of the patients was 65.2 years (microtile interval 61-69 years). Amino acids were determined and the ratio between them. According to the results of Holter ECG monitoring (of HMCG) evaluated HRV. Results: in patients with PICS compared with healthy individuals observed a significant decrease in the blood levels of Tau/Ala (at 51.01%, p<0.001). The presence of comorbid diabetes is accompanied by more significant decrease in Tau/Ala (for the accounting period 82.22%, p<0.001) compared to healthy individuals. Between Tau/Ala and SDNN, LF, TP, VLF power of communication has been high, between Tau/Ala and RMSSD, HF, pNN 50.%, ULF, – moderate strength. Conclusions: the lower values of Tau/Ala in the blood of patients Pxs diabetes compared with patients without disorders of carbohydrate metabolism, accompanied by a decrease in spectral and temporal parameters of HRV, but that does not mean a causal relationship, may be associated with pathogenetic mechanisms of disorders of carbohydrate metabolism and requires further research.
Посилання
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Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., ... & Jiménez, M. C. (2017). Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation, 135(10), e146-e603.
Bi, X., & Henry, C. J. (2017). Plasma-free amino acid profiles are predictors of cancer and diabetes development. Nutrition & diabetes, 7(3), e249.
Boos, C., Vincent, E., Mellor, A., O Hara, J., Newman, C., Cruttenden, R., ... & Woods, D. R. (2017). The effect of sex on heart rate variability at high altitude. Medicine and science in sports and exercise, 49(12), 2562-2569.
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Chen, J., Yang, S. B., Liu, J., & Tang, Z. H. (2015). Diagnostic performance analysis for diabetic cardiovascular autonomic neuropathy based on short-term heart rate variability using Bayesian methods: preliminary analysis. Diabetology & metabolic syndrome, 7(1), 74.
Geidenstam, N., Danielsson, A. P., Spégel, P., & Ridderstråle, M. (2016). Changes in glucose-elicited blood metabolite responses following weight loss and long term weight maintenance in obese individuals with impaired glucose tolerance. Diabetes research and clinical practice, 113, 187-197.
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Kuang, D., Yang, R., Chen, X., Lao, G., Wu, F., Huang, X., ... & Ou, S. (2017). Depression recognition according to heart rate variability using Bayesian Networks. Journal of psychiatric research, 95, 282-287.
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Sarapultsev, P., Yushkov, B., & Sarapultsev, A. (2017). Prevalence of arrhythmias in patients with type 2 diabetes and the role of structural changes in myocardium in their development. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 11, S567-S576.
Sessa, F., Anna, V., Messina, G., Cibelli, G., Monda, V., Marsala, G., ... & Pisanelli, D. (2018). Heart rate variability as predictive factor for sudden cardiac death. Aging (Albany NY), 10(2), 166.
Stewart, R. M., Hood, S. D., Rao, P., Moore, J. K., Runions, K. C., Murphy, S. E., ... & Zepf, F. D. (2018). Using acute tryptophan depletion to investigate predictors of treatment response in adolescents with major depressive disorder: study protocol for a randomised controlled trial. Trials, 19(1), 434.
Triggiani, A. I., Valenzano, A., Ciliberti, M. A. P., Moscatelli, F., Villani, S., Monda, M., ... & Cibelli, G. (2017). Heart rate variability is reduced in underweight and overweight healthy adult women. Clinical physiology and functional imaging, 37(2), 162-167.
Walker, A. M., & Cubbon, R. M. (2015). Sudden cardiac death in patients with diabetes mellitus and chronic heart failure. Diabetes and Vascular Disease Research, 12(4), 228-233.
Zheng, Y., Ceglarek, U., Huang, T., Li, L., Rood, J., Ryan, D. H., ... & Shai, I. (2016). Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials–3. The American journal of clinical nutrition, 103(2), 505-511.
Andrikopoulos, G. K., Pastromas, S., & Tzeis, S. (2015). Flecainide: current status and perspectives in arrhythmia management. World journal of cardiology, 7(2), 76.
Avetisyan, E. A., Petrosyan, A. A., Khachiyan, M. S., Saakyan, N. A., Simonyan, L. Y., & Shogheryan, S. A. (2017). The role of taurine in adaptation of visceral systems under psycho-emotional stress in rats. Journal of Evolutionary Biochemistry and Physiology, 53(1), 37-45.
Barman, M. (2015). Proarrhythmic effects of antiarrhythmic drugs: Case study of flecainide induced ventricular arrhythmias during treatment of atrial fibrillation. Journal of atrial fibrillation, 8(4).
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., ... & Jiménez, M. C. (2017). Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation, 135(10), e146-e603.
Bi, X., & Henry, C. J. (2017). Plasma-free amino acid profiles are predictors of cancer and diabetes development. Nutrition & diabetes, 7(3), e249.
Boos, C., Vincent, E., Mellor, A., O Hara, J., Newman, C., Cruttenden, R., ... & Woods, D. R. (2017). The effect of sex on heart rate variability at high altitude. Medicine and science in sports and exercise, 49(12), 2562-2569.
Boulet, M. M., Chevrier, G., Grenier-Larouche, T., Pelletier, M., Nadeau, M., Scarpa, J., ... & Tchernof, A. (2015). Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk. American Journal of Physiology-Endocrinology and Metabolism, 309(8), E736-E746.
Chen, J., Yang, S. B., Liu, J., & Tang, Z. H. (2015). Diagnostic performance analysis for diabetic cardiovascular autonomic neuropathy based on short-term heart rate variability using Bayesian methods: preliminary analysis. Diabetology & metabolic syndrome, 7(1), 74.
Geidenstam, N., Danielsson, A. P., Spégel, P., & Ridderstråle, M. (2016). Changes in glucose-elicited blood metabolite responses following weight loss and long term weight maintenance in obese individuals with impaired glucose tolerance. Diabetes research and clinical practice, 113, 187-197.
Hosford, P. S., Millar, J., & Ramage, A. G. (2015). Cardiovascular afferents cause the release of 5‐HT in the nucleus tractus solitarii; this release is regulated by the low‐(PMAT) not the high‐affinity transporter (SERT). The Journal of physiology, 593(7), 1715-1729.
Huang, W. A., Boyle, N. G., & Vaseghi, M. (2017). Cardiac innervation and the autonomic nervous system in sudden cardiac death. Cardiac electrophysiology clinics, 9(4), 665-679.
Krishna, K., Jha, Y., Tuteja, A., Adukia, S., Dharamsi, S., & Chauhan, R. (2015). Probing into arrhythmias in type 2 diabetics. Indian J Appl Res, 5, 781-3.
Kuang, D., Yang, R., Chen, X., Lao, G., Wu, F., Huang, X., ... & Ou, S. (2017). Depression recognition according to heart rate variability using Bayesian Networks. Journal of psychiatric research, 95, 282-287.
Ma, Y., Tseng, P. H., Ahn, A., Wu, M. S., Ho, Y. L., Chen, M. F., & Peng, C. K. (2017). Cardiac autonomic alteration and metabolic syndrome: an ambulatory ECG-based study in a general population. Scientific reports, 7, 44363.
Page, R. L., O’Bryant, C. L., Cheng, D., Dow, T. J., Ky, B., Stein, C. M., ... & Lindenfeld, J. (2016). Drugs that may cause or exacerbate heart failure: a scientific statement from the American Heart Association. Circulation, 134(6), e32-e69.
Piccolo, B. D., Comerford, K. B., Karakas, S. E., Knotts, T. A., Fiehn, O., & Adams, S. H. (2015). Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial. The Journal of nutrition, 145(4), 691-700.
Powers, A. C., Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L., Jameson, J. L., & Loscalzo, J. (2015). Diabetes mellitus: complications. Kasper DL. Hauser SL, Jameson JL, Fauci AS, Longo DL, Loscalzo J, editors. Harrison’s principles of internal medicine. 19th ed. Philadelphia: McGraw Hill, 2422-5.
Ramírez, J., Orini, M., Mincholé, A., Monasterio, V., Cygankiewicz, I., de Luna, A. B., ... & Pueyo, E. (2017). Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model. PloS one, 12(10), e0186152.
Sarapultsev, P., Yushkov, B., & Sarapultsev, A. (2017). Prevalence of arrhythmias in patients with type 2 diabetes and the role of structural changes in myocardium in their development. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 11, S567-S576.
Sessa, F., Anna, V., Messina, G., Cibelli, G., Monda, V., Marsala, G., ... & Pisanelli, D. (2018). Heart rate variability as predictive factor for sudden cardiac death. Aging (Albany NY), 10(2), 166.
Stewart, R. M., Hood, S. D., Rao, P., Moore, J. K., Runions, K. C., Murphy, S. E., ... & Zepf, F. D. (2018). Using acute tryptophan depletion to investigate predictors of treatment response in adolescents with major depressive disorder: study protocol for a randomised controlled trial. Trials, 19(1), 434.
Triggiani, A. I., Valenzano, A., Ciliberti, M. A. P., Moscatelli, F., Villani, S., Monda, M., ... & Cibelli, G. (2017). Heart rate variability is reduced in underweight and overweight healthy adult women. Clinical physiology and functional imaging, 37(2), 162-167.
Walker, A. M., & Cubbon, R. M. (2015). Sudden cardiac death in patients with diabetes mellitus and chronic heart failure. Diabetes and Vascular Disease Research, 12(4), 228-233.
Zheng, Y., Ceglarek, U., Huang, T., Li, L., Rood, J., Ryan, D. H., ... & Shai, I. (2016). Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials–3. The American journal of clinical nutrition, 103(2), 505-511.
Опубліковано
2019-04-05
Як цитувати
Belikova, J. (2019). THE RELATIONSHIP OF THE RATIO TAURINE/ALANINE IN SERUM AND INDICATORS OF HEART RATE VARIABILITY IN PATIENTS WITH POSTINFARCTION CARDIOSCLEROSIS AND DIABETES MELLITUS TYPE 2. Український науково-медичний молодіжний журнал, (1(109), 6-10. https://doi.org/10.32345/USMYJ.1(109).2019.6-10
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