EXTRACELLULAR POLYMERIC SUBSTANCE OF BIOFILMS IN THE FORMATION OF ANTIMICROBIAL RESISTANCE OF MICROORGANISMS

Olexandra  Kovalenko; Yaroslav Kizim; Natalia Voroshylova

doi:10.32345/USMYJ.2(110).2019.6-12

Olexandra Kovalenko Bogomolets National Medical University
Yaroslav Kizim National Academy of Medical Sciences of Ukraine prof. O.S. Kolomiychenko Institute of Otolaryngology
Natalia Voroshylova Candidate of biological sciences, National Academy of Medical Sciences of Ukraine prof. O.S. Kolomiychenko Institute of Otolaryngology

DOI: https://doi.org/10.32345/USMYJ.2(110).2019.6-12

Анотація

Abstract. The analysis of modern literature data on the mechanisms of the formation of antibiotic resistance and the role of extracellular polymeric substance in biofilms, which are the main form of microbial existence. The role of extracellular polymeric substance in limiting of the effect of unfavorable factors as well as the regularity and necessity of its formation for the community of microorganisms were discussed. The position on the permanent character of phenotype dispersion of microorganisms is postulated. This dispersion doesn’t provide the formation of more resistant strains only, but plays the prominent role in the permanent formation of various forms, that aren’t viable under given conditions but play the role of a depot of building material for extracellular polymeric substance. The mass death of low-resistant forms caused by the action of the antibiotic ensures saturation of the extracellular polymeric substance by dechromatized DNA, that increases the resistance of the microbial socium and contributes to the further formation of multiresistance.

Посилання

Antimicrobal resistance: global report on survelliance 2014. WHO (April 2014), 256 p.
Antimicrobal Resistance Benchmark 2018. Methodology report. Access to medical foundation. Amsterdam, 2017, 42 p.
Babady, N. (2016). Hospital-associated infections. In: Microbiology of Immunocompromized Host. Randall, T., Hayden, D., Karen, C., et al, Eds, Amer. Soc. Microbiol., 735-758.
Brinkmann, V., Reichard, U., Goosmann, C., et al. (2004). Neutrophil extracellular traps koll bacteria. Science, 303, 1532-1535.
Dyachenko, A. G. (2012). Fntimicrobal resistance and its evolution // Klin. Immunology. Fllergology. Infectology (Rus.), 4, 5-11.
Flemming, H., Wingender, J., Szewzyk, U., et al. (2016). Biofilms: an Emergent Form of Bacterial Life. Nat. Rev Microbiol., 14, 563-575.
Flemming, H. (2016) EPS – then and now. Microorgainsms, 4, 437-444.
Fuchs, T., Abed, U., Goosmann, C., et al. (2007). Novel cellular death program leads to neutrophil extracellular trap. J. Cell. Biol., 176, 231-241.
Hazen, T., Mettus, R., McElhey, C., et al. (2018). Diversity among blaKPC-containing plasmids in Escherichia coli and other bacterial species isolated from the same patients. Nature Sci. Reports., 8, 10291.
Hoffman, S., Outterson, K., Rottigen, G., et al. (2015). An international legal framework to address antimicrobial resistance. Bulletin of the World Health Organization, 93(2), 66 p.
Huseby, M., Kruse, A., Digre, J., et al. (2010). Beta toxin catalyses formation of nucleoprotein matrix in staphylococcal biofilms. Proc. Natl. Acad. Sci USA., 107, 14407-14412.
Kamiunke, N., Herzsprung, P., & Neu, T. (2015). Quality of dissolved organic matter affects planctonic but not biofilm bacterial production in streams. Sci. Total Environ., 506-507, 353-360.
Mahfouz, N., Caucci, S., Achatz, E., et al. (2018). High genomic diversity of multidrug resistant wasrwater Escherichia coli. Nature, Sci. Reports, 8, 8928.
Man, T., Pitts, B., Pellock. B., et al. (2003). Agenetic basis for Pseudomonas aeriginosa biofilm antibiotic resistance. Nature, 426, 306-310.
Namazova-Baranova, L., & Baranov, A. (2017). Antibiotic resistance in modern world. Pediarticheskaya Farmakologia (Rus.), 14, 341-354.
Nikolaev, Yu., Plakunov, V. (2007). Biofilm – “City of Microbes” or an Analogue of Multicellular Organisms? Microbilolgy, 76, 125-138.
O’Neill, J. (2014). Antimicrobal resistance tacking a crisis for the health and wealth of nations. The Review on Antimicrobal Resistance. YM Government, London, 20 p.
Seiler, C., Berendonk, T. (2012). Heavy metal driven co-selection of antibiotic resistance in soil and water bodies impacted by agriculture and aquaculture. Frontiers in Microbiol., 3, 399.
Taglialegna, A., Lasa, I., Valle, J. (2016). Amyloid structures as biofilm matrix scaffolds. J. Bacteriol., 198, 2579-2588.
Tang, L., Schramm, A. & Neu, T. (2013). Extracellular DNA in adhesion and biofilm formation of four environmental isolates. A quantitative study. FEMS Microbiol., 86, 394-403.
Vert, M., Doi, Y., Hellwich, K-H., Hess, M., et al. (2012). Terminology for biorelated polymers and applications (IUPAC Recommendations 2012). Pure Appl Chem., 84, 377-410.
Vilain, S., Pretorius, J., Theron, J., et al. (2009). DNA as an adhesion: Bacillus cereus requires extracellular DNA to form biofilm. Appl. Environ. Microbiol., 75, 2861-2868.