ІМУНОГІСТОХІМІЧНА ХАРАКТЕРИСТИКА ЕКСПРЕСІЇ MMP-9 TAVEGF В ДОБРОЯКІСНІИХТА ЗЛОЯКІСНИХ МЕНІНГІОМАХ ГОЛОВНОГО МОЗКУ
Анотація
Резюме. С помощью иммуногистохимического метода исследования нами была проанализирована экспрессия ММР-9 та VEGF в образцах доброкачественных и злокачественных менингиом, удаленных во время нейрохирургических операций у 36 больных. В результате исследования было установлено, что анапластические менингиомы характеризуются достоверно большими уровнями экспрессии ММР-9 и VEGF, чем доброкачественные, при этом, уровень экспрессии ММР-9 связан с рецидивом опухолей. С помощью корреляционного анализа было выявлено, что между ММР- 9 и VEGF существуют достоверные прямые связи.
Посилання
1. WHO Classification of Tumors of the Central Nervous System / Eds D.N. Louis [et al.]. — Geneva, 2007. - 309 p.
2. Prognostic significance ofiKi-67/MIB-l proliferation index in meningiomas / S.H. Torp, C.F. Lindboe, B.H. Gronberg [et al.] // Clin. Neuropathol. - 2005. - Vol.24, N2 4. - P. 170-174.
3. Meningioma grading: an analysis of histologic parameters / A. Perry, S.L. Stafford, B.W. Scheithauer [et al.] //Am. J. Surg. Pathol. - 1997. - Vol.21, N2 12. - P. 1455-1465.
4. Von Randow A. J. Expression of extracellular matrix degrading proteins in classic, atypical and anaplastic meningiomas / A.J. Von Randow, S. Schindler, D.S.Tews //Pathol. Res. Pract. — 2006. — Vol.202, N2 5. - P. 365—372.
5. Increased co-expression of macrophage migration inhibitory factor and matrix metalloproteinase 9 is associated with tumor recurrence of meningioma / H. Quan, Zh. Song-Li, T. Xiao-Ying [et al.] // Int. J. Med. Sci. —2013. - Vol. 10, №>3. - P. 276^-285.
6. Farina A.R. Gelatinase B/MMP-9 in tumour pathogenesis and progression / A.R. Farina, A.R. Mackay // Cancers. — 2014, Vol. 6, №1. - P. 240-296.
7. Krstic J. Transforming growth factor-beta and matrix metalloproteinases functional interplay in cancer; implications in epithelial to mesenchymal transition / J. Krstic, J.F. Santibanez // Cell Biol: Res. Ther. - 2014. - doi: 10.4172/2324-9293.S1-004.
8. Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas / A.T. Panagopoulos, C.L. Lancellotti, J.C. Veiga [et al.] //J. Neurooncol. - 2008. - Vol.89, №>1. - P. 73-87.
9. MMP-9 expression in meningiomas: a prognostic marker for recurrence risk? / V. Barresi, E. Vitarelli, G. Tuccari [et al.] //
J. Neurooncol. - 2011. - Vol.102, N22. - P. 189-196.
10. Barresi V. Angiogenesis in meningiomas / V. Barresi // Brain Tumor Pathol. - 2011. - Vol.28, N22. - P. 99-106.
11. Tubular network formation by adriamycin-resistant MCF-7 breast cancer cells is closely linked to MMP-9 and VEGFR-2/VEGFR- 3 over-expression / A. Karoum, P. Mirshahi, A.-M. Faussat [et al.] // Mol. Cell. Pharmacol. — 2012. — № 685. — P. 1—7.
12. Expression of MMP-2 and -9 in short-term cultures of meningioma: influence of histological subtype / H.K. Rooprai, T.E. van Meter, S.D. Robinson [et al.] // Int. J. Mol. Med. — 2003. — N212.— P. 977—981.
13. Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas / E. Iwado, T. Ichikawa, H. Kosaka [et al.] // Neuropathology. — 2012. — Vol.32, N26. - P. 638-646.
14. Dharmalingam P. Vascular endothelial growth factor expression and angiogenesis in various grades and subtypes of meningioma / P.Dharmalingam, VR Roopesh Kumar, SK. Verma // Indian J. Pathol. Microbiol. — 2013. — V.56, N24. — P.349-354.
2. Prognostic significance ofiKi-67/MIB-l proliferation index in meningiomas / S.H. Torp, C.F. Lindboe, B.H. Gronberg [et al.] // Clin. Neuropathol. - 2005. - Vol.24, N2 4. - P. 170-174.
3. Meningioma grading: an analysis of histologic parameters / A. Perry, S.L. Stafford, B.W. Scheithauer [et al.] //Am. J. Surg. Pathol. - 1997. - Vol.21, N2 12. - P. 1455-1465.
4. Von Randow A. J. Expression of extracellular matrix degrading proteins in classic, atypical and anaplastic meningiomas / A.J. Von Randow, S. Schindler, D.S.Tews //Pathol. Res. Pract. — 2006. — Vol.202, N2 5. - P. 365—372.
5. Increased co-expression of macrophage migration inhibitory factor and matrix metalloproteinase 9 is associated with tumor recurrence of meningioma / H. Quan, Zh. Song-Li, T. Xiao-Ying [et al.] // Int. J. Med. Sci. —2013. - Vol. 10, №>3. - P. 276^-285.
6. Farina A.R. Gelatinase B/MMP-9 in tumour pathogenesis and progression / A.R. Farina, A.R. Mackay // Cancers. — 2014, Vol. 6, №1. - P. 240-296.
7. Krstic J. Transforming growth factor-beta and matrix metalloproteinases functional interplay in cancer; implications in epithelial to mesenchymal transition / J. Krstic, J.F. Santibanez // Cell Biol: Res. Ther. - 2014. - doi: 10.4172/2324-9293.S1-004.
8. Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas / A.T. Panagopoulos, C.L. Lancellotti, J.C. Veiga [et al.] //J. Neurooncol. - 2008. - Vol.89, №>1. - P. 73-87.
9. MMP-9 expression in meningiomas: a prognostic marker for recurrence risk? / V. Barresi, E. Vitarelli, G. Tuccari [et al.] //
J. Neurooncol. - 2011. - Vol.102, N22. - P. 189-196.
10. Barresi V. Angiogenesis in meningiomas / V. Barresi // Brain Tumor Pathol. - 2011. - Vol.28, N22. - P. 99-106.
11. Tubular network formation by adriamycin-resistant MCF-7 breast cancer cells is closely linked to MMP-9 and VEGFR-2/VEGFR- 3 over-expression / A. Karoum, P. Mirshahi, A.-M. Faussat [et al.] // Mol. Cell. Pharmacol. — 2012. — № 685. — P. 1—7.
12. Expression of MMP-2 and -9 in short-term cultures of meningioma: influence of histological subtype / H.K. Rooprai, T.E. van Meter, S.D. Robinson [et al.] // Int. J. Mol. Med. — 2003. — N212.— P. 977—981.
13. Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas / E. Iwado, T. Ichikawa, H. Kosaka [et al.] // Neuropathology. — 2012. — Vol.32, N26. - P. 638-646.
14. Dharmalingam P. Vascular endothelial growth factor expression and angiogenesis in various grades and subtypes of meningioma / P.Dharmalingam, VR Roopesh Kumar, SK. Verma // Indian J. Pathol. Microbiol. — 2013. — V.56, N24. — P.349-354.
Опубліковано
2015-09-24
Як цитувати
Вотєва, В., & Тертишний, С. (2015). ІМУНОГІСТОХІМІЧНА ХАРАКТЕРИСТИКА ЕКСПРЕСІЇ MMP-9 TAVEGF В ДОБРОЯКІСНІИХТА ЗЛОЯКІСНИХ МЕНІНГІОМАХ ГОЛОВНОГО МОЗКУ. Український науково-медичний молодіжний журнал, 3(89), 73-76. вилучено із http://mmj.nmuofficial.com/index.php/journal/article/view/222
Розділ
Медицина
