СУЧАСНІ АСПЕКТИ ПАТОГЕНЕЗУ СИСТЕМНИХ НЕКРОТИЗУЮЧИХ ВАСКУЛІТІВ
Ключові слова:
: системні некротизуючі васкуліти, патогенез, антинейтрофільні цитоплазматичні антитіла, ендотелій-1, антитіла до лізосомального мембранного протеїну-2, фактор активації В-кпітин
Анотація
У даній статті представлені літературні дані останніх років щодо патогенезу системних некротизуючих васкулитов. Продемонстровано патогенетичну роль антинейтрофільних цитоплазматических антитіл, антитіл до протеїну-2 лізосомальної мембрани, ендотелію і маркерів його дисфункції, Т- і В-лімфоцитів у розвитку даної патології. Виявлені особливості патогенезу повинні бути основою для створення нових ефективних методів лікування хворих системними некротизуючим васкулитами.
Посилання
1. Watts R.A. Epidemiology of vasculitis / R.A. Watts, D.G. Scott// Vasculitis. 2nded. Oxford: Oxford University Press. —2008. -P. 7-22.
2. Казимирко В.К., Коваленко В.EL. /Ревматология: учебное пособие для врачей в вопросах и ответах, До^ нецк. —2009. — 626с.
3. Vidosava В. Endothelial Cells and Vasculitis /B.J. Vidosava, V. yKosijK , L. ZvezdanovijK-HelebijK, et al. //
Advances in the Etiology, Pathogenesis and Pathology of Vasculitis, book edited by Luis M. Amezcua-Guerra. — 2011. — P. 154-178.
4. Cid M.C. Endothelial cell biology, perivascular inflammation, and vasculitis/M.C. Cid//Clev. Clin. J. Med. — 2002. - Vol. 69. - P. 1145-1149.
5. Bacon P.A. Endothelial cell dysfunction in systemic vasculitis: new developments and therapeutic prospects / P.A. Bacon// Curr. Opin. Rheumatol. — 2005. — Vol. 17. — P. 49-55.
6. Zouki C. Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ETA receptors and platelet-activatingfactor / C. Zouki, C. Baron, A. Fournier, J.G. Filep//Br. J. Pharmacol. — 1999. — Vol. 127.— P. 969-979.
7. Selman M. Idiopathic pulmonary fibrosis: pathogene¬sis and therapeutic approaches / M. Selman, V.J. Thannickal, A. Pardo, et al. //Drugs. — 2004. — Vol. 64. — P. 405-430.
8. Pache M. Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis/
MPache, etal.//Med. Sci.Monit. — 2002. — Vol. 8. — P. 616-619.
9. Julkunen H. Raised plasma concentrations of endothelin-1 in systemic lupus erythematosus/Н. Julkunen,
O. Saijonmaa, etal.//Ann. Rheum. Dis. — 1991. — Vol. 50. —
P. 526- 527.
10. FerriC. Increased plasma endothelin-1 immunoreactive levels in vasculitis: a clue to the use of endothelin-1 as a marker of vascular damage / C. Ferri, A. Latorraca, G. Cata- pano, F. Greco, etal.// J. Hypertens. Suppl. — 1993. — Vol.
11. - P. 142-S143.
11. Muslu A. Endothelin levels in Henoch-Schonlein purpura/А. Muslu, I. Islek, F. Gok, etal.//Pediatr. Nephrol. — 2002. - Vol. 17.-P. 920-925.
12. Lozano E. Increased expression of the endothelin
system in arterial lesions from patients with giant-cell arteritis: association between elevated endothelin
plasma levels and the development of ischemic events / E. Lozano, M. Segarra, M. Corbera-Bellalta, A. Garcna- Mar'nez, et al. //Ann. Rheum. Dis. — 2010. — Vol. 69. — P. 434-442.
13. McIntyre T.M. Cell-cell interactions: leukocyte- endothelial interactions / T.M. McIntyre, S.M. Prescott, et al//Curr. Opin. Hematol. — 2003. — Vol. 10. — P. 150-158.
14. Wilde B. New pathophysiological insights and treatment of ANCA-associated vasculitis / B. Wilde, P. Paassen, О. Witzke, J. Tervaert//Kidney International. — 2011. - Vol. 59. - P. 599-612.
15. Sanders J. S. Plasma levels of soluble interleukin 2 receptor, soluble CD30, interleukin 10 andB cell activator of the tumour necrosis factor family during follow-up in vasculitis associated with proteinase 3-antineutrophil cytoplasmic antibodies: associations with disease activity and relapse / J. S. Sanders, M. G. Huitma, et al. //Ann. Rheum. Dis. - 2006. - Vol. 65. - P. 1484-1489.
16. Mueller A. Germinal centre-like structures in Wegener's granuloma: the morphological basis for autoimmunity / Mueller, А., К. Holl-Ulrich, et al. // Rheumatology (Oxford). -2008. - Vol. 47. -P. 1111-1113.
17.Shlomchik M. J. From T to В and back again: positive feedback in systemic autoimmune disease / M.J. Shlomchik, J. E. Craft, M. J. Mamula//Nat. Rev. Immu¬nol. -2001. - Vol.200. -P. 147-153.
18. Voswinkel J. В lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions /J. Voswinkel, A. Mueller, J. A. Kraemer, P. Lamprecht, K. Herlyn, K. Holl-Ulrich, A. C. Feller,
S. Pitann, A. Gause and W. L. Gross //Ann. Rheum. Dis. - 2006. - Vol. 1200. -P. 859-864.
19. Schneeweis C. Increased levels ofBLySandsVCAM-1 in anti-neutrophil cytoplasmatic antibody (ANCA)-associa¬ted vasculitides (AAV) /С. Schneeweis M., F. E. Rafalowicz, etal. //Clin. Exp. Rheumatol. -2010. - Vol.28. - P. 62-66.
20. Scapini P. Proinflammatory mediators elicit secret tion of the intracellular В-lymphocytes stimulate pool (BlyS) that is stored in activated neutrophils: implication for inflammatory diseases/ P. Scapini, A. Carletto, B. Nardelli, F. Calzetti, et al.//Blood. -2005. - Vol.2. - P. 830-837.
21. Bader L. B-lymphocyte activatingfactor levels are increased in patients withWegener's granulomatosis and inversely correlated with ANCA titer / L. Bader, W. Kol- dingsnes, J. Nossent// Clin. Rheumatol. - 2010. - Vol.29. - P. 1031-1035.
22. Kain R. Molecular mimicry in pauciimmune focal necrotizing glomerulonephritis / R. Kain, M. Exner, R. Brandes, et al. //Nat. Med. -2008. - Vol. 14. - P. 1088— 1096.
23. Kawakami T. Serum Anti-lysosomal-associated Membrane Protein-2 Antibody Levels in Cutaneous Poly¬arteritis Nodosa/ T. Kawakami, A. Akihiro Ishizu, Y. Arimura and Y.Somal //Acta. Derm. Venereol.- 2014. - Vol.93. - P. 70-73.
2. Казимирко В.К., Коваленко В.EL. /Ревматология: учебное пособие для врачей в вопросах и ответах, До^ нецк. —2009. — 626с.
3. Vidosava В. Endothelial Cells and Vasculitis /B.J. Vidosava, V. yKosijK , L. ZvezdanovijK-HelebijK, et al. //
Advances in the Etiology, Pathogenesis and Pathology of Vasculitis, book edited by Luis M. Amezcua-Guerra. — 2011. — P. 154-178.
4. Cid M.C. Endothelial cell biology, perivascular inflammation, and vasculitis/M.C. Cid//Clev. Clin. J. Med. — 2002. - Vol. 69. - P. 1145-1149.
5. Bacon P.A. Endothelial cell dysfunction in systemic vasculitis: new developments and therapeutic prospects / P.A. Bacon// Curr. Opin. Rheumatol. — 2005. — Vol. 17. — P. 49-55.
6. Zouki C. Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ETA receptors and platelet-activatingfactor / C. Zouki, C. Baron, A. Fournier, J.G. Filep//Br. J. Pharmacol. — 1999. — Vol. 127.— P. 969-979.
7. Selman M. Idiopathic pulmonary fibrosis: pathogene¬sis and therapeutic approaches / M. Selman, V.J. Thannickal, A. Pardo, et al. //Drugs. — 2004. — Vol. 64. — P. 405-430.
8. Pache M. Elevated plasma endothelin-1 levels and vascular dysregulation in patients with rheumatoid arthritis/
MPache, etal.//Med. Sci.Monit. — 2002. — Vol. 8. — P. 616-619.
9. Julkunen H. Raised plasma concentrations of endothelin-1 in systemic lupus erythematosus/Н. Julkunen,
O. Saijonmaa, etal.//Ann. Rheum. Dis. — 1991. — Vol. 50. —
P. 526- 527.
10. FerriC. Increased plasma endothelin-1 immunoreactive levels in vasculitis: a clue to the use of endothelin-1 as a marker of vascular damage / C. Ferri, A. Latorraca, G. Cata- pano, F. Greco, etal.// J. Hypertens. Suppl. — 1993. — Vol.
11. - P. 142-S143.
11. Muslu A. Endothelin levels in Henoch-Schonlein purpura/А. Muslu, I. Islek, F. Gok, etal.//Pediatr. Nephrol. — 2002. - Vol. 17.-P. 920-925.
12. Lozano E. Increased expression of the endothelin
system in arterial lesions from patients with giant-cell arteritis: association between elevated endothelin
plasma levels and the development of ischemic events / E. Lozano, M. Segarra, M. Corbera-Bellalta, A. Garcna- Mar'nez, et al. //Ann. Rheum. Dis. — 2010. — Vol. 69. — P. 434-442.
13. McIntyre T.M. Cell-cell interactions: leukocyte- endothelial interactions / T.M. McIntyre, S.M. Prescott, et al//Curr. Opin. Hematol. — 2003. — Vol. 10. — P. 150-158.
14. Wilde B. New pathophysiological insights and treatment of ANCA-associated vasculitis / B. Wilde, P. Paassen, О. Witzke, J. Tervaert//Kidney International. — 2011. - Vol. 59. - P. 599-612.
15. Sanders J. S. Plasma levels of soluble interleukin 2 receptor, soluble CD30, interleukin 10 andB cell activator of the tumour necrosis factor family during follow-up in vasculitis associated with proteinase 3-antineutrophil cytoplasmic antibodies: associations with disease activity and relapse / J. S. Sanders, M. G. Huitma, et al. //Ann. Rheum. Dis. - 2006. - Vol. 65. - P. 1484-1489.
16. Mueller A. Germinal centre-like structures in Wegener's granuloma: the morphological basis for autoimmunity / Mueller, А., К. Holl-Ulrich, et al. // Rheumatology (Oxford). -2008. - Vol. 47. -P. 1111-1113.
17.Shlomchik M. J. From T to В and back again: positive feedback in systemic autoimmune disease / M.J. Shlomchik, J. E. Craft, M. J. Mamula//Nat. Rev. Immu¬nol. -2001. - Vol.200. -P. 147-153.
18. Voswinkel J. В lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions /J. Voswinkel, A. Mueller, J. A. Kraemer, P. Lamprecht, K. Herlyn, K. Holl-Ulrich, A. C. Feller,
S. Pitann, A. Gause and W. L. Gross //Ann. Rheum. Dis. - 2006. - Vol. 1200. -P. 859-864.
19. Schneeweis C. Increased levels ofBLySandsVCAM-1 in anti-neutrophil cytoplasmatic antibody (ANCA)-associa¬ted vasculitides (AAV) /С. Schneeweis M., F. E. Rafalowicz, etal. //Clin. Exp. Rheumatol. -2010. - Vol.28. - P. 62-66.
20. Scapini P. Proinflammatory mediators elicit secret tion of the intracellular В-lymphocytes stimulate pool (BlyS) that is stored in activated neutrophils: implication for inflammatory diseases/ P. Scapini, A. Carletto, B. Nardelli, F. Calzetti, et al.//Blood. -2005. - Vol.2. - P. 830-837.
21. Bader L. B-lymphocyte activatingfactor levels are increased in patients withWegener's granulomatosis and inversely correlated with ANCA titer / L. Bader, W. Kol- dingsnes, J. Nossent// Clin. Rheumatol. - 2010. - Vol.29. - P. 1031-1035.
22. Kain R. Molecular mimicry in pauciimmune focal necrotizing glomerulonephritis / R. Kain, M. Exner, R. Brandes, et al. //Nat. Med. -2008. - Vol. 14. - P. 1088— 1096.
23. Kawakami T. Serum Anti-lysosomal-associated Membrane Protein-2 Antibody Levels in Cutaneous Poly¬arteritis Nodosa/ T. Kawakami, A. Akihiro Ishizu, Y. Arimura and Y.Somal //Acta. Derm. Venereol.- 2014. - Vol.93. - P. 70-73.
Як цитувати
Петелицька, Л. (1). СУЧАСНІ АСПЕКТИ ПАТОГЕНЕЗУ СИСТЕМНИХ НЕКРОТИЗУЮЧИХ ВАСКУЛІТІВ. Український науково-медичний молодіжний журнал, 1(1), 72-74. вилучено із http://mmj.nmuofficial.com/index.php/journal/article/view/470
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