ДИСМЕТАБОЛІЗМ ХРЯЩОВОЇ ТКАНИНИ У ХВОРИХ НА ОСТЕОАРТРОЗ: ЛАБОРАТОРНО-ІНСТРУМЕНТАЛЬНА ДІАГНОСТИКА ТА ШЛЯХИ МЕДИКАМЕНТОЗНОЇ КОРЕКЦІЇ
Ключові слова:
остеоартроз, фактори ризику, матриксні металопротеїнази, С-кінцевий телопептид колагену 2-ого типу, олігомерний матриксний протеїн, ультразвукове дослідження, магнітно-резонансна томографія, хворобо-модифікуючі препарати
Анотація
У даній статті представлені результати досліджень особливостей ураження хрящової тканини у хворих на остеоартроз. Продемонстровано патогенетична роль С-термінального телопептиду колагену 2-го типу, олігомерного матриксного протеїну, матриксних металопротеїназ у розробці хряща, можливість ранньої діагностики та корекції дісметабо- лизма хрящової тканини у хворих на остеоартроз.
Посилання
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2. Abramson S. B. Developments in the scientific under-standing of osteoarthritis/S. B. Abramson, M. Attur//Arthri¬tis Research & Therapy. — 2009. — Vol. 11 (3). — P. 227.
3. Anderson A. S. Why is Оsteoarthritis an Age-Related Disease/А. S Anderson, R. F. Loeser//Best Practice & Re¬search Clinical Rheumatology. — 2010. — Vol. 24(1). — P. 15.
4. Bonnelye E. Estrogen receptor—related receptor 6
regulation by interleukin-le in prostaglandin E2— and cAMP-dependent pathways in оsteoarthritic chondrocytes / E. Bonnelye, etal.//Arthritis & Rheumatism. — 2011 August. — Vol. 63(8). P. 2374 2384.
5. Boyan B. D. Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee /В. D. Boyan, D. A. Hart, R. M. Enoka, et al. // Biology of Sex Differences — 2013. — Vol. 4(1). — P. 3.
6. Braun M. Pentosidine, an Advanced Glycation End- Product, May Reflect Clinical and Morphological Features of Hand Osteoarthritis / M. Braun, H. Hulejov6, J. Gatterov6, et al. // The Open Rheumatology Journal. —
2012. — Vol. 6. — P. 64--69.
оsteoarthritic chondrocytes /1. Papathanasiou, K.N. Ma- lizos, A. Tsezou // Arthritis Research & Therapy. - 2012. - Vol. 14 (2). - P. 82.
18. Pelletier J. P. Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis / J. P. Pelletier,
J.P. Raynauld, J. Caron, et al. //Ann. Rheum/Dis. -2010. - Vol. 69. -P. 2095-2101.
19. Pulsatelli L. New findings in osteoarthritis pathogenesis: therapeutic implications/Е. Pulsatelli, О. Ad- dimanda, V. Brusi, et al.// Therap. Advances in Chronic Dis. -
2013. -Vol. 4(1). -P. 23-43.
20. Reginster J-Y. Efficacy and safety of strontium
7. Calabro P. Obesity, inflammation, andvascular disease: ranelate in the treatment of knee osteoarthritis: results of a the role of the adipose tissue as an endocrine organ/P. Calabro, double-blind, randomised placebo-controlled trial /J-Y. E. T. Yeh//SubcellularBiochem.—2007. — Vol. 42. — P. 63—91Reginster, J. Badurski, M. Bellamy //Annals Rheumatic
8. Chu C.R. Early diagnosis to enable early treatment of pre-osteoarthritis/C. R. Chu, A. A. Williams, С. H. Coyle, eyal. Arthritis Research & Therapy. — 2012. — Vol. 14(3). — P. 212.
9. Ding C. Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study/ C. Ding, V. Parameswaran, F. Cicuttini, etal.//Ann. Rheum. Dis. — 2008. — Vol. 67(9). — P. 1256-1261.
10. Goldring M. B. Cartilage homeostasis in health and rheumatic diseases /Магу В G. andK. B. Marcu //Arthritis Research & Therapy. — 2009. — Vol. 11(3). — P. 224.
11. Goldring M.B. Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis / Mary B. Goldring // Therapeutic Advances in Musculoskeletal Disease. — 2012 August. —
Vol. 4(4). — P. 269—285.
12. Henrotin Y. Chondroitin Sulfate in the Treatment of О steo arthritis: From in Vitro Studies to Clinical Recommendations/ Y. Henrotin, M. Mathy, C. Sanchez, et al. // Therapeutic Advances in Musculoskeletal Disease. — 2010December. — Vol. 2(6). — P. 335—348.
13. Hochberg M. C. Osteoarthritis and related disorders. InM. C. Hochberg, A. J. Silman, J.S. Smolen, etal.//Rheuma¬tology 5th edn. Philadelphia: Mosby. — 2010. — P. 1709—1836
14. Keisuke I. Anti-arthritic action mechanisms of natural chondroitin sulfate in human articular chondrocytes and synovial fibroblasts /1. Keisuke, H. Oka, D. Kawasaki, et al. //Biological & Pharmaceutical Bulletin. — 2010. — Vol. 33 (3). - P. 410 - 414.
15. Koskinen A. Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors
through mitogen-activated protein kinase pathways / A. Koskinen, S. Juslin, R. Nieminen, et al. //Arthritis Research & Therapy. — 2011. — Vol. 13 (6). — P. 184.
16. Loeser R. F. Age-Related Changes in the Musculoskeletal System and the Development of Оsteoarthritis/R. F. Loeser//Clinics in Geriatric Medicine. — 2010August. — Vol. 26(3). — P. 371 — 386.
17. Papathanasiou I. Bone morphogenetic protein-2- induced Wnt/e-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related
protein 5 catabolic activity contributes to hypertrophy in
Diseases. -2013- Vol. 72. - P. 179-186.
// 21. ReginsterJ- Y. Role of glucosamine in the treatmentfor
osteoarthritis / J-Y Reginster, A. Neuprez, M-P. Lecart, etal.// Rheum. International. - 2012. - Vol. 32 (10). - P. 2959 - 2967.
22. Rego-Pwrez I. Mitochondrial. DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis /1. Rego-Purez, M. Femondez-Moreno, M. Deberg, et al. // Annals Rheumatic Diseases. - 2010. - Vol. 69. -P. 910-917.
23. Ringdahl E. Treatment of Knee Osteoarthritis / E. Ringdahl, S. Pandit//American Family Physician. - 2011. - Vol. 83 (11). -P. 1287-1292.
24. Saltzherr S. M. Metric properties of advanced imaging methods in osteoarthritis of the hand: systematic review/M.S. Saltzherr, R.W. Selles, S.M. Bierma-Zeinstra, et al. Ann. Rheum. Dis. -2012 . -Vol. 20. -P. 2515.
25. Stannus O. Circulating levels of 1L-6 and TNF-6 are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults / O. Stannus, G. Jones, F. Cir- cuttini, etal. // Ostearthritis Cartilage. - 2010 November. - Vol. 18 (11). -P. 1441-1447.
26. TroebergL. Proteases involved in cartilage matrix degra dation in osteoarthritis /L. Troeberg, H. Nagase //Biochimica etBiophysicaActa. -2012. - Vol. 1824(1). -P. 133-145.
27. WangY. Use magnetic resonance imaging to assess ar-ticular cartilage/Y. Wang, A. E. Wluka, G. Jones//Ther. Advan¬ces in Musculoskeletal Dis. - 2012. - Vol. 4 (2). - P. 77-97.
28. WarrellD.A. Rheumatological disorders. InD.A. War¬rell, T.M. Cox., J.D. Firth// Oxford Textbook ofMedicine 5th edn. USA: Oxford University Press. -2010. -P. 1709-1837.
29. Wei Z. Adiponectin receptor 1 the difference in adiponectin induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts / Z. Wei, W. Zhi-hong, W. Nan, etal. // Chinese Medical Journal. - 2011. Vol. 124 (23). -P. 3919-3924.
30. Yusuf E. Association between weight or body mass index and hand osteoarthritis: a systematic review /Е. Yusuf R. G Nelissen, A. Ioan-Facsinay, et al. Ann. Rheum. Dis. - 2010. - Vol. 69. -P. 761 - 765.
31. Zweers M. C. Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis /M. C. Zweers, T. N. de Boer, J. van Roon, et al. // Arthritis Research & Therapy. -2011 - Vol. 13 (5). -P. 239.
2. Abramson S. B. Developments in the scientific under-standing of osteoarthritis/S. B. Abramson, M. Attur//Arthri¬tis Research & Therapy. — 2009. — Vol. 11 (3). — P. 227.
3. Anderson A. S. Why is Оsteoarthritis an Age-Related Disease/А. S Anderson, R. F. Loeser//Best Practice & Re¬search Clinical Rheumatology. — 2010. — Vol. 24(1). — P. 15.
4. Bonnelye E. Estrogen receptor—related receptor 6
regulation by interleukin-le in prostaglandin E2— and cAMP-dependent pathways in оsteoarthritic chondrocytes / E. Bonnelye, etal.//Arthritis & Rheumatism. — 2011 August. — Vol. 63(8). P. 2374 2384.
5. Boyan B. D. Hormonal modulation of connective tissue homeostasis and sex differences in risk for osteoarthritis of the knee /В. D. Boyan, D. A. Hart, R. M. Enoka, et al. // Biology of Sex Differences — 2013. — Vol. 4(1). — P. 3.
6. Braun M. Pentosidine, an Advanced Glycation End- Product, May Reflect Clinical and Morphological Features of Hand Osteoarthritis / M. Braun, H. Hulejov6, J. Gatterov6, et al. // The Open Rheumatology Journal. —
2012. — Vol. 6. — P. 64--69.
оsteoarthritic chondrocytes /1. Papathanasiou, K.N. Ma- lizos, A. Tsezou // Arthritis Research & Therapy. - 2012. - Vol. 14 (2). - P. 82.
18. Pelletier J. P. Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis / J. P. Pelletier,
J.P. Raynauld, J. Caron, et al. //Ann. Rheum/Dis. -2010. - Vol. 69. -P. 2095-2101.
19. Pulsatelli L. New findings in osteoarthritis pathogenesis: therapeutic implications/Е. Pulsatelli, О. Ad- dimanda, V. Brusi, et al.// Therap. Advances in Chronic Dis. -
2013. -Vol. 4(1). -P. 23-43.
20. Reginster J-Y. Efficacy and safety of strontium
7. Calabro P. Obesity, inflammation, andvascular disease: ranelate in the treatment of knee osteoarthritis: results of a the role of the adipose tissue as an endocrine organ/P. Calabro, double-blind, randomised placebo-controlled trial /J-Y. E. T. Yeh//SubcellularBiochem.—2007. — Vol. 42. — P. 63—91Reginster, J. Badurski, M. Bellamy //Annals Rheumatic
8. Chu C.R. Early diagnosis to enable early treatment of pre-osteoarthritis/C. R. Chu, A. A. Williams, С. H. Coyle, eyal. Arthritis Research & Therapy. — 2012. — Vol. 14(3). — P. 212.
9. Ding C. Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study/ C. Ding, V. Parameswaran, F. Cicuttini, etal.//Ann. Rheum. Dis. — 2008. — Vol. 67(9). — P. 1256-1261.
10. Goldring M. B. Cartilage homeostasis in health and rheumatic diseases /Магу В G. andK. B. Marcu //Arthritis Research & Therapy. — 2009. — Vol. 11(3). — P. 224.
11. Goldring M.B. Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis / Mary B. Goldring // Therapeutic Advances in Musculoskeletal Disease. — 2012 August. —
Vol. 4(4). — P. 269—285.
12. Henrotin Y. Chondroitin Sulfate in the Treatment of О steo arthritis: From in Vitro Studies to Clinical Recommendations/ Y. Henrotin, M. Mathy, C. Sanchez, et al. // Therapeutic Advances in Musculoskeletal Disease. — 2010December. — Vol. 2(6). — P. 335—348.
13. Hochberg M. C. Osteoarthritis and related disorders. InM. C. Hochberg, A. J. Silman, J.S. Smolen, etal.//Rheuma¬tology 5th edn. Philadelphia: Mosby. — 2010. — P. 1709—1836
14. Keisuke I. Anti-arthritic action mechanisms of natural chondroitin sulfate in human articular chondrocytes and synovial fibroblasts /1. Keisuke, H. Oka, D. Kawasaki, et al. //Biological & Pharmaceutical Bulletin. — 2010. — Vol. 33 (3). - P. 410 - 414.
15. Koskinen A. Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors
through mitogen-activated protein kinase pathways / A. Koskinen, S. Juslin, R. Nieminen, et al. //Arthritis Research & Therapy. — 2011. — Vol. 13 (6). — P. 184.
16. Loeser R. F. Age-Related Changes in the Musculoskeletal System and the Development of Оsteoarthritis/R. F. Loeser//Clinics in Geriatric Medicine. — 2010August. — Vol. 26(3). — P. 371 — 386.
17. Papathanasiou I. Bone morphogenetic protein-2- induced Wnt/e-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related
protein 5 catabolic activity contributes to hypertrophy in
Diseases. -2013- Vol. 72. - P. 179-186.
// 21. ReginsterJ- Y. Role of glucosamine in the treatmentfor
osteoarthritis / J-Y Reginster, A. Neuprez, M-P. Lecart, etal.// Rheum. International. - 2012. - Vol. 32 (10). - P. 2959 - 2967.
22. Rego-Pwrez I. Mitochondrial. DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis /1. Rego-Purez, M. Femondez-Moreno, M. Deberg, et al. // Annals Rheumatic Diseases. - 2010. - Vol. 69. -P. 910-917.
23. Ringdahl E. Treatment of Knee Osteoarthritis / E. Ringdahl, S. Pandit//American Family Physician. - 2011. - Vol. 83 (11). -P. 1287-1292.
24. Saltzherr S. M. Metric properties of advanced imaging methods in osteoarthritis of the hand: systematic review/M.S. Saltzherr, R.W. Selles, S.M. Bierma-Zeinstra, et al. Ann. Rheum. Dis. -2012 . -Vol. 20. -P. 2515.
25. Stannus O. Circulating levels of 1L-6 and TNF-6 are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults / O. Stannus, G. Jones, F. Cir- cuttini, etal. // Ostearthritis Cartilage. - 2010 November. - Vol. 18 (11). -P. 1441-1447.
26. TroebergL. Proteases involved in cartilage matrix degra dation in osteoarthritis /L. Troeberg, H. Nagase //Biochimica etBiophysicaActa. -2012. - Vol. 1824(1). -P. 133-145.
27. WangY. Use magnetic resonance imaging to assess ar-ticular cartilage/Y. Wang, A. E. Wluka, G. Jones//Ther. Advan¬ces in Musculoskeletal Dis. - 2012. - Vol. 4 (2). - P. 77-97.
28. WarrellD.A. Rheumatological disorders. InD.A. War¬rell, T.M. Cox., J.D. Firth// Oxford Textbook ofMedicine 5th edn. USA: Oxford University Press. -2010. -P. 1709-1837.
29. Wei Z. Adiponectin receptor 1 the difference in adiponectin induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts / Z. Wei, W. Zhi-hong, W. Nan, etal. // Chinese Medical Journal. - 2011. Vol. 124 (23). -P. 3919-3924.
30. Yusuf E. Association between weight or body mass index and hand osteoarthritis: a systematic review /Е. Yusuf R. G Nelissen, A. Ioan-Facsinay, et al. Ann. Rheum. Dis. - 2010. - Vol. 69. -P. 761 - 765.
31. Zweers M. C. Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis /M. C. Zweers, T. N. de Boer, J. van Roon, et al. // Arthritis Research & Therapy. -2011 - Vol. 13 (5). -P. 239.
Як цитувати
Федьков, Д. (1). ДИСМЕТАБОЛІЗМ ХРЯЩОВОЇ ТКАНИНИ У ХВОРИХ НА ОСТЕОАРТРОЗ: ЛАБОРАТОРНО-ІНСТРУМЕНТАЛЬНА ДІАГНОСТИКА ТА ШЛЯХИ МЕДИКАМЕНТОЗНОЇ КОРЕКЦІЇ. Український науково-медичний молодіжний журнал, 1(1), 79-83. вилучено із http://mmj.nmuofficial.com/index.php/journal/article/view/472
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