Pharmaceutical care in the use of vitamin-mineral complexes for women during pregnancy and lactation

  • Temirova Оlena Department of Clinical Pharmacology and Clinical Pharmacy of Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0002-9752-6898
  • Bondarenko Alina Department of Clinical Pharmacology and Clinical Pharmacy of Bogomolets National Medical University, Kyiv, Ukraine
  • Khaitovych Mykola Department of Clinical Pharmacology and Clinical Pharmacy of Bogomolets National Medical University, Kyiv, Ukraine https://orcid.org/0000-0001-6412-3243
Keywords: pregnancy, lactation, vitamins, minerals, fetal development, pharmaceutical services

Abstract

during pregnancy and breastfeeding, the need for micronutrients increases, and their insufficient supply negatively affects both the health of the woman and the development of the child. However, the irrational use of large doses of certain vitamins and minerals has risks comparable to their deficiency. The purpose of this study: is to investigate the role of pharmaceutical care in the use of vitamin and mineral complexes for women during pregnancy and breastfeeding based on a questionnaire. The study involved 100 women of different ages. Most respondents lived in cities (90 %). Almost 60 % of women had one childbirth, 25 % had two and 7 % had three childbirths. It was found that about 90 % of respondents breastfeed. Almost half of the women surveyed developed symptoms of hypovitaminosis during pregnancy/breastfeeding. Respondents observed such symptoms of hypovitaminosis as changes in the structure and loss of hair (70 %), changes in the structure of nails (40 %), and the development of dermatitis (27 %). However, no statistically significant differences were found between the incidence of hypovitaminosis symptoms in breastfeeding and non-breastfeeding women. Whereas women over the age of 26 were more likely to experience symptoms of hypovitaminosis compared to younger women (p<0.05). It was found that 97 % of respondents took vitamin and mineral complexes for normal fetal development (81 %), prevention (29 %), and treatment (28 %) of hypovitaminosis, in acute respiratory viral infections (7 %). About 77 % of women took the complex throughout pregnancy, during lactation – 22 %. Respondents took vitamin and mineral complexes as prescribed by a doctor (75 %), recommendations from Internet resources (13 %), advice from a pharmacist (10 %), and relatives/acquaintances (9 %). The choices were: folic acid (65 %), «Elevit Pronatal» (42 %), iron (25 %), «Vitrum Prenatal», and «Femibion» (12 %). Most respondents used vitamin and mineral complexes as a course (86 %), while 15 % took to normalize the condition, 4 % – one month. Almost half of the surveyed women (48 %), mostly those who noted the appearance of symptoms of hypovitaminosis (p<0.05), took several vitamin and mineral supplements. While more than 60 % in the complex took other groups of drugs. It was found that most respondents believe that vitamin and mineral supplements are safe for use in women during pregnancy and lactation. However, almost 10 % noted the appearance of complications after their use, namely: hair loss, changes in nail condition, dermatitis, and indigestion. Therefore, providing quality pharmaceutical care in the release of vitamin and mineral complexes for women during pregnancy and lactation is an important condition for safe and effective pharmacotherapy. Pharmacists influence the rational choice of vitamin-mineral complexes, prevent their uncontrolled use, and provide recommendations on the mode and duration of administration and the peculiarities of interaction with other drugs and foods.

References

Антомонов М.Ю. (2017). Математическая обработка и анализ медико-биологических данных. (Оригінал опубліковано 2 р.).

Булавенко, О. В., Фурман, О. В., Таран, О. А., & Льовкіна, О. Л. (2019). A modern obstetrician-gynecologists' view on the multivitamin complexes for pregnant women. Reproductive Endocrinology, (47), 64–67. https://doi.org/10.18370/2309-4117.2019.47.64-67

Ведення фізіологічної вагітності. (2012). Україно-швейцарська програма «Здоров`я матері та дитини».

Гавриленко Л. Н., Кожанова И. Н., & Сачек М. М. (2013). Беременность и лекарственные средства.Фармакоэпидемиологическое исследование. Здравоохранение, (11), 28–33.

Ермоленко, Т. А., & Турчин, Н. И. (2019). “Better less, but better”: A new philosophy of vitamin and mineral complexes use in the pregnancy and breastfeeding periods. Reproductive Endocrinology, (47), 68–72. https://doi.org/10.18370/2309-4117.2019.47.68-72

Максимович Н. М. (2017). Оптимізація фармацевтичної допомоги при захворюваннях у жінок [Неопубл. дис. канд. фармацевт. наук]. Львівський національний медичний університет імені Данила Галицького.

Щербина М. О., Мерцалова О. В., & Юркова О. В. (2018). Принципи раціональної фармакотерапії в акушерстві : Метод. вказ. для підготовки студентів VI курсу до державної атестації.

Aparicio, E., Jardí, C., Bedmar, C., Pallejà, M., Basora, J., & Arija, V. (2020). Nutrient Intake during Pregnancy and Post-Partum: ECLIPSES Study. Nutrients, 12(5), 1325. https://doi.org/10.3390/nu12051325

Busso, D., David, A., Penailillo, R., Echeverría, G., Rigotti, A., Kovalskys, I., Gómez, G., Cortés Sanabria, L., Yépez García, M., Pareja, R., Herrera-Cuenca, M., & Fisberg, M. (2021). Intake of vitamin E and C in women of reproductive age: Results from the latin american study of nutrition and health (ELANS). Nutrients, 13(6), 1954. https://doi.org/10.3390/nu13061954

Dutra, L. V., Souza, F. I. S. d., & Konstantyner, T. (2021). Effects of vitamin d supplementation during pregnancy on newborns and infants: An integrative review. Revista Paulista De Pediatria, 39. https://doi.org/10.1590/1984-0462/2021/39/2020087

Gernand, A. D., Schulze, K. J., Stewart, C. P., West, K. P., & Christian, P. (2016). Micronutrient deficiencies in pregnancy worldwide: Health effects and prevention. Nature Reviews Endocrinology, 12(5), 274–289. https://doi.org/10.1038/nrendo.2016.37

Hrynkiv, Y. O., Blavatska O. B., Yatskova, G. Y., & Zaliska O. M. (б. д.). Analysis of the vitamin’s list with pharmacoeconomic rates for the treatment of long covid conditions during the pandemic COVID-19 in ukraine. Farmatsevtychnyi Zhurnal, (5), 16–26. https://doi.org/10.32352/0367-3057.5.21.02

Jeremy Rafael Tandaju, Saptawati Bardosono, & Metta Dewi. (2021). The link between vitamin A dietary status and anaemia in pregnancy: A comparative cross-sectional study. J Pak Med Assoc ., 71(2), 123–128.

Juhl, B., Lauszus, F. F., & Lykkesfeldt, J. (2019). Glycemic control during pregnancy—a predictor of vitamin C status at labor in type 1 diabetic women? Antioxidants, 8(6), 153. https://doi.org/10.3390/antiox8060153

Kiely, M. E., Wagner, C. L., & Roth, D. E. (2020). Vitamin D in pregnancy: Where we are and where we should go. The Journal of Steroid Biochemistry and Molecular Biology, 201, 105669. https://doi.org/10.1016/j.jsbmb.2020.105669

King, J. C. (2000). Determinants of maternal zinc status during pregnancy. The American Journal of Clinical Nutrition, 71(5), 1334S—1343S. https://doi.org/10.1093/ajcn/71.5.1334s

Liu, C., Zhong, C., Chen, R., Zhou, X., Wu, J., Han, J., Li, X., Zhang, Y., Gao, Q., Xiao, M., Hu, X., Xiong, G., Han, W., Yang, X., Hao, L., & Yang, N. (2020). Higher dietary vitamin C intake is associated with a lower risk of gestational diabetes mellitus: A longitudinal cohort study. Clinical Nutrition, 39(1), 198–203. https://doi.org/10.1016/j.clnu.2019.01.015

McCauley, M. E., van den Broek, N., Dou, L., & Othman, M. (2015). Vitamin A supplementation during pregnancy for maternal and newborn outcomes. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd008666.pub3

Myerson, R., Crawford, S., & Wherry, L. R. (2020). Medicaid expansion increased preconception health counseling, folic acid intake, and postpartum contraception. Health Affairs, 39(11), 1883–1890. https://doi.org/10.1377/hlthaff.2020.00106

Oliveira, J. M., Allert, R., & East, C. E. (2016). Vitamin A supplementation for postpartum women. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd005944.pub3

Ota, E., Mori, R., Middleton, P., Tobe-Gai, R., Mahomed, K., Miyazaki, C., & Bhutta, Z. A. (2015). Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd000230.pub5

Sharna J. Coker, Carlos C. Smith-Díaz, Rebecca M. Dyson, Margreet C. M. Vissers, & Mary J. Berry. (2022). The epigenetic role of vitamin C in neurodevelopment. J. Mol. Sci., 23.

Sijing Duan, Yong Jiang, Kai Mou, Yi Wang, Shanshan Zhou, & Bingxin Sun 5. (2021). Correlation of serum vitamin A and vitamin E levels with the occurrence and severity of preeclampsia. Am J Transl Res, 13(12), 203–210.

T. B. Ryvak, O. M. Nepyivoda, & A. Ya Koval. (2020). Фармацевтична опіка при симптомах алергії під час вагітності та лактації: Раціональний вибір і застосування антигістамінних лікарських засобів. Запорізький медичний журнал, 2(22), 192–199.

WHO. (2011). Guideline : Vitamin A supplementation in pregnant women.

WHO. (2016). Recommendations on antenatal care for a positive pregnancy experience.

Wolf, H. T., Hegaard, H. K., Huusom, L. D., & Pinborg, A. B. (2017). Multivitamin use and adverse birth outcomes in high-income countries: A systematic review and meta-analysis. American Journal of Obstetrics and Gynecology, 217(4), 404.e1–404.e30. https://doi.org/10.1016/j.ajog.2017.03.029

Published
2022-09-28
How to Cite
1.
TemirovaО, Bondarenko A, Khaitovych M. Pharmaceutical care in the use of vitamin-mineral complexes for women during pregnancy and lactation. USMYJ [Internet]. 2022Sep.28 [cited 2026Mar.21];132(3):58-7. Available from: https://mmj.nmuofficial.com/index.php/journal/article/view/105
Section
Pharmacy, industrial pharmacу