D dimer as Biomarker for Covid-19 severity

Nameera  Parveen Shaikh; Aleena  Parveen Shaikh; Ia  Murvanidze; Eteri  Saralidze; Irina  Nakashidze

doi:10.32345/USMYJ.4(142).2023.48-54

Nameera Parveen Shaikh Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia https://orcid.org/0000-0002-7393-0263
Aleena Parveen Shaikh Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia https://orcid.org/0000-0002-1473-4334
Ia Murvanidze Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia https://orcid.org/0000-0002-2351-9177
Eteri Saralidze Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia https://orcid/org/0000-0001-6841-1525
Irina Nakashidze Faculty of Natural Sciences and Health Care, Batumi Shota Rustaveli State University, Batumi, Georgia https://orcid.org/0000-0001-8934-6312

DOI: https://doi.org/10.32345/USMYJ.4(142).2023.48-54

Keywords: COVID-19, Biomarkers, Severity, Comorbidity, Mortality

Abstract

Coronavirus infectious disease 2019 (COVID-19) infections, a highly coagulative and inflammatory state, predispose patients to arterial and venous thrombotic events due to platelet activation, endothelial dysfunction, and stasis. There are several reasons why elevated levels of D-dimer indicate the severity of the disease. This review paper aims to revise the significance of D-dimer levels in the covid-19. Thus, according to the studies, the increase in D-dimer level was significantly associated with the severity of the disease's course and the mortality rate. Moreover, in the case of mortality of hospitalized patients, a very high level of D-dimer is detected, which confirms that D-dimer can be used as a valuable biomarker for evaluating clinical outcomes in patients with Covid-19.

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