АНТИБІОТИКИ В СТОМАТОЛОГІЇ

Taras Bondar

doi:10.32345/USMYJ.2(116).2020.15-24

Taras Bondar Department of Surgical Dentistry of the Dental Medical Center, Bogomolets National Medical University, Kyiv, Ukraine.

DOI: https://doi.org/10.32345/USMYJ.2(116).2020.15-24

Keywords: antibiotics, antibiotic resistance, oral infections, surgical dentistry, dental procedures.

Abstract

The article summarizes the arguments and counter-arguments within the scientific discussion on the use of antibiotics in dentistry. The main purpose of the study is to analyze various clinical situations that require the use of antimicrobial drugs. The research method was based on the study of scientific articles published in the period from 2005 to 2019 and indexed in Ukraine and international databases, as well as a comparison of different recommendations for the appointment of antibiotics in dentistry, published in developed countries. Systematization of literature sources and approaches to solving the problem of prevention and treatment of purulent-inflammatory infections in dentistry has shown that antibiotics used in different countries around the world, converge on the rational and reasonable use of antimicrobial drugs. The vast majority of researchers believe that antibiotics should be used only in recommended situations for patients at risk of developing purulent-inflammatory infections after dental procedures. However, the question of the rational use of both prevention and empirical treatment of infections with antibiotics in dentistry remains unresolved. This is primarily due to the constant change in biological properties, including resistance to antibiotics of pathogens of purulent-inflammatory infections of the oral cavity. Only a few studies are devoted to this topic, and there are no modern data in the available literature. In Ukraine, there are no officially approved recommendations for the use of antibiotics in dentistry. There is also no state-level epidemiological surveillance for resistance to infectious agents, including the oral cavity. In addition, the question of the effectiveness of the use of antibiotics in dentistry has not been studied. Additional research is needed to study the emergence and spread of antimicrobial-resistant microorganisms in health care facilities, including in outpatient settings and the use of antibiotics by dentists, which, according to some international guidelines, seem widespread and not limited to situations that described in the guidelines of associations of dentists in developed countries. Therefore, dentists should be careful in the use of antibiotics, both for the treatment and prevention of infections, and prescribe antibiotics only if recommended by guidelines based on the results of evidence-based medicine, as well as effectively and safely.

References

Салманов А.Г. (2015). Антимікробна резистентність та інфекції, асоційовані з медичною допомогою в Україні. Епідеміологічний звіт мультіцентрового дослідження (2010-2014 рр.). / Монографія / А.Г. Салманов .– К.: Аграр Медіа Груп – 2015. – 452 с. ISBN 978-617-646-325-2.

Салманов, А.Г. (2012). Антибіотикорезистентність в хірургії: Монографія / Салманов А.Г., Марієвський В.Ф., Бойко В.В., Іоффе І.В., Тарабан І.А.– Х.: НТМТ. – 2012. – 456 с. ISBN 978-617-578-092-3.

Agnihotry A, Thompson W, Fedorowicz Z, van Zuuren EJ, Sprakel J. Antibiotic use for irreversible pulpitis. Cochrane Database Syst Rev. 2019;5(5):CD004969.

Agarwal E, Bajaj P, Naik SB, Pradeep AR. Locally delivered 0.5% azithromycin as an adjunct to non-surgical treat- ment in patients with chronic periodontitis with type 2 diabetes: A randomized controlled clinical trial. J Periodontol 2017; 88(12): 1281-7.

Andreasen JO, Storgård Jensen S, Sae-Lim V. The role of antibiotics in preventing healing complications after trau- matic dental injuries: A literature review. Endod Topics 2006; 14(1): 80-92.

Arteagoitia I, Diez A, Barbier L, Santamaría G, Santamaría J. Efficacy of amoxicillin/clavulanic acid in preventing infectious and inflammatory complications following impacted mandibular third molar extraction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 100(1): e11-8.

Arteagoitia, M.I., Barbier, L., Santamaría J, Santamaría G, Ramos E. (2016). Efficacy of amoxicillin and amoxicillin/ clavulanic acid in the prevention of infection and dry socket after third molar extraction. A systematic review and me- ta-analysis. Med Oral Patol Oral Cir Bucal 2016; 21(4): e494-504.

Barone A, Giannoni M, Ortu E, Monaco A, Pietropaoli D. Short-term and Long-lasting effects of hypo-cariogenic dietary advice and oral care on oral flora: A randomised clinical trial. Oral Health Prev Dent 2018; 16(4): 315-25..

Bătăiosu M, Taisescu CI, Pisoschi CG, et al. (2015). Effects of therapy with two combinations of antibiotics on the imbalance of MMP-2÷TIMP-2 in chronic periodontitis. Rom J Morphol Embryol 2015; 56(1): 77-83.

Chung WC, Tu YK, Lin YH, Lu HK. (2014). Outcomes of autotransplanted teeth with complete root formation: A systematic review and meta-analysis. J Clin Periodontol 2014; 41(4): 412-23.

Cope A, Francis N, Wood F, Mann MK, Chestnutt IG. Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults. Cochrane Database Syst Rev 2014; (6): CD010136.

Cope AL, Francis N, Wood F, Chestnutt IG. Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults. Cochrane Database Syst Rev 2018; 9CD010136

Eick S, Nydegger J, Bürgin W, Salvi GE, Sculean A, Ramseier C. Microbiological analysis and the outcomes of peri- odontal treatment with or without adjunctive systemic antibiotics- A retrospective study. Clin Oral Investig 2018; 22(9): 3031-41.

Elias C, Moja L, Mertz D, Loeb M, Forte G, Magrini N. Guideline recommendations and antimicrobial resistance: The need for a change. BMJ Open 2017; 7(7): e016264

Goodson JM, Hartman ML, Shi P, et al. The salivary microbiome is altered in the presence of a high salivary glucose concentration. PLoS One 2017; 12(3)e0170437

Holmberg P, Hellmich T, Homme J. Pediatric sepsis secondary to an occult dental abscess: A case report. J Emerg Med 2017; 52(5): 744-8.

Isola G, Matarese M, Ramaglia L, Iorio-Siciliano V, Cordasco G, Matarese G. (2019a). Efficacy of a drug composed of herbal extracts on postoperative discomfort after surgical removal of impacted mandibular third molar: A randomized, triple-blind, controlled clinical trial. Clin Oral Investig 2019; 23(5): 2443-53.

Isola G, Matarese M, Ramaglia L, Cicciù M, Matarese G. (2019b). Evaluation of the efficacy of celecoxib and ibupro- fen on postoperative pain, swelling, and mouth opening after surgical removal of impacted third molars: A randomized, controlled clinical trial. Int J Oral Maxillofac Surg 2019; 48(10): 1348-54.

Isla A., Canut A., Rodríguez-Gascón A., Planells P., Beltrí-Orta P., et al. (2008). Antibiotic therapy in odontogen- ic infections in children and adolescents: pharmacokinetic/pharmacodynamic analysis. Enferm Infecc Microbiol Clin. 2008;26(10):621-628. doi:10.1016/s0213-005x(08)75278-9.

Kan P, Sasaki H, Inaba K, Watanabe K, Hamada N, Minabe M. Inhibitory effects of azithromycin on the adherence ability of Porphyromonas gingivalis. J Periodontol 2019; 90(8): 903-10.

Kapoor A, Malhotra R, Grover V, Grover D. Systemic antibiotic therapy in periodontics. Dent Res J (Isfahan) 2012; 9(5): 505-15.

Kurtzman GM, Hughes MK. (2015). Evolution of comprehensive care, Part 3. Periodontal treatment continues to evolve. Dentistry Today 2015; 34(5): 90, 2, 4-7.

Lewis MA. Why we must reduce dental prescription of antibiotics: European Union Antibiotic Awareness Day. Br Dent J 2008; 205(10): 537-8.

Lodi G, Figini L, Sardella A, Carrassi A, Del Fabbro M, Furness S. Antibiotics to prevent complications following tooth extractions. Cochrane Database Systematic Rev 2012; 11 CD003811.

Mainjot A, D’Hoore W, Vanheusden A, Van Nieuwenhuysen JP. (2009). Antibiotic prescribing in dental practice in Belgium. Int Endod J 2009; 42(12): 1112-7.

Marouane OTB, Oualha L, Douki N. (2017). Tooth replantation: An update. Med Buccale Chirurgie Buccale 2017; 23(2): 103-10.

Marthaler TM. (2004). Changes in dental caries 1953-2003. Caries Res 2004; 38(3): 173-81.

Melo ME, Silva CA, de Souza Gomes WD, et al. Immediate tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline. Clin Oral Investig 2016; 20(3): 523-32.

Nastri L, De Rosa A, De Gregorio V, Grassia V, Donnarumma G. (2019). A new controlled-release material contain- ing metronidazole and doxycycline for the treatment of periodontal and peri-implant diseases: Formulation and in vitro testing. Int J Dent 2019; 2019: 10.

Nishimura RA, Otto CM, Bonow RO, et al. (2014a). ACC/AHA Task Force Members. 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014; 129(23): 2440-92.

Nishimura RA, Otto CM, Bonow RO, et al. (2014b). AHA/ACC guideline for the management of patients with val- vular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014; 63(22): e57-e185.

Nishimura RA, Otto CM, Bonow RO, et al. (2014c). ACC/AHA Task Force Members. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation 2014; 129(23): e521-643.

O’Rourke VJ. (2017). Azithromycin as an adjunct to non-surgical periodontal therapy: A systematic review. Aust Dent J 2017; 62(1): 14-22.

Ortu E, Sgolastra F, Barone A, Gatto R, Marzo G, Monaco A. (2014). Salivary Streptococcus Mutans and Lactobacillus spp. levels in patients during rapid palatal expansion. Eur J Paediatr Dent 2014; 15(3): 271-4.

Parirokh M, V Abbott P. (2014). Various strategies for pain-free root canal treatment. Iran Endod J 2014; 9(1): 1-14. Perić M, Perković I, Romić M, et al. (2015). The pattern of antibiotic prescribing by dental practitioners in Zagreb,

Croatia. Cent Eur J Public Health 2015; 23(2): 107-13.

Pietropaoli D, Del Pinto R, Ferri C, et al. (2018). Poor oral health and blood pressure control Among US Hypertensive Adults. Results From : National Health and Nutrition Examination Survey 2009-2014. Hypertension (Dallas, Tex : 1979) 2018; 72(6): 1365-73.

Pietropaoli D, Del Pinto R, Ferri C, Ortu E, Monaco A. (2019). Definition of hypertension-associated oral pathogens in NHANES. J Periodontol 2019; 90(8): 866-76.

Prakasam A, Elavarasu SS, Natarajan RK. (2012). Antibiotics in the management of aggressive periodontitis. J Pharm Bioallied Sci 2012; 4(Suppl. 2): S252-5.

Putt MS, Mallatt ME, Messmann LL, Proskin HM. (2014). A 6-month clinical investigation of custom tray application of peroxide gel with or without doxycycline as adjuncts to scaling and root planing for treatment of periodontitis. Am J Dent 2014; 27(5): 273-84.

Rodriguez-Núñez A, Cisneros-Cabello R, Velasco-Ortega E, Llamas-Carreras JM, Tórres-Lagares D, Segura-Egea JJ. (2009). Antibiotic use by members of the spanish endodontic society. J Endod 2009; 35(9): 1198-203.

Rodriguez Sanchez F, Rodriguez Andres C, Arteagoitia I. (2018). Which antibiotic regimen prevents implant failure or infection after dental implant surgery? A systematic review and meta-analysis. J Cranio-Maxillofac Surg 2018; 46(4): 722-36.

Reynolds-Campbell G, Nicholson A, Thoms-Rodriguez CA. (2017). Oral bacterial infections: Diagnosis and manage- ment. Dent Clin North Am 2017; 61(2): 305-18.

Salmanov, A.G. (2018). Ukrainian Strategy and Action Plan for the Prevention of Healthcare Association Infections (HAIs) and Antimicrobial Resistance. International Journal of Antibiotics and Probiotics. 2018; 2-3 (4):6-23.

Samaranayake, L., Matsubara VH. (2017). Normal oral flora and the oral ecosystem. Dent Clin North Am 2017; 61(2): 199-215.

Segura-Egea JJ, Gould K, Sen BH. (2018). European Society of Endodontology position statement: The use of antibi- otics in endodontics 2018; 51(1): 20-5.

Segura-Egea JJ, Gould K, Şen BH, et al. (2017). Antibiotics in Endodontics: A review. Int Endod J 2017; 50(12): 1169-84.

Segura-Egea, J.J., Velasco-Ortega E, Torres-Lagares D, Velasco-Ponferrada MC, Monsalve-Guil L, Llamas-Carreras JM. (2010). Pattern of antibiotic prescription in the management of endodontic infections amongst Spanish oral surgeons. Int Endod J 2010; 43(4): 342-50.

Sollecito TP, Abt E, Lockhart PB, et al. (2015). The use of prophylactic antibiotics prior to dental procedures in pa- tients with prosthetic joints: Evidence-based clinical practice guideline for dental practitioners--a report of the American Dental Association Council on Scientific Affairs. J Am Dent Assoc. 2015;146(1):11-16.e8.

Tacconelli E, Pezzani MD. (2019). Public health burden of antimicrobial resistance in Europe. Lancet Infect Dis 2019; 19(1): 4-6.

van Winkelhoff AJ, Winkel EG. (2009). Antibiotics in periodontics: right or wrong? J Periodontol 2009; 80(10): 1555-8.

Waglechner N, Wright GD. (2017). Antibiotic resistance: it’s bad, but why isn’t it worse? BMC Biol 2017; 15(1): 84.

Zandbergen D, Slot DE, Niederman R, Van der Weijden FA. (2016). The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: A systematic review. BMC Oral Health 2016; 16: 27.

ANTIBIOTICS IN DENTISTRY

Abstract

References