FEATURES OF WARFARIN INFLUENCE ON PLATELET FATTY ACID SPECTRUM IN ISCHEMIC HEART DISEASE PATIENTS WITH DIFFENT ATRIAL FIBRILLATION CLINICAL FORMS
Abstract
Clinical protocols do not provide us an exact data about optimal scheme of anticoagulant therapy in patients with coronary artery disease (CHD) with atrial fibrillation (AF). It is known that warfarin directly affects fatty acids (FA) exchange in the body - potentiates the effect of omega-3 FA, and reduces the content of omega-6 FA. Although the effect of warfarin on the fatty acid spectrum (FAS) of platelet membranes phospholipids (PL) is still not fully understood. It was found that FAS PL platelets membranes of healthy people is characterized by the absence of myristic, pentadecanic, margarinic and linoleic FA. In patients with coronary heart disease compared to the control group (CG) there is a significant decrease in the relative content of stearic, arachidonic FA and a significant increase in the relative content of oleic acid in platelets PL membranes. In patients with CHD and AF, there is a significant decrease in the relative content of myristic, stearic, arachidonic FA, as well as a significant increase in the relative content of palmitic, oleinic and linoleic FA in PL platelet membranes, indicating the presence of structural changes in platelet membranes in patients with atrial fibrillation.To be one of the pathogenetic links of atrial fibrillation in these patients. Warfarin therapy in CHD with permanent AF patients led to a significant increase in the relative content of myristic (20,99%), stearic (15,17%) and arachidonic (34,04%) acids, which is a sign of cellular stabilization membranes, and in the presence of paroxysmal or persistent form of AF in PL membranes of platelets, the relative content of stearic acid increased (by 44.70%). Patients with coronary artery disease, in combination with a permanent form of AF, the appointment of a pharmacotherapy scheme that includes warfarin is more desirable because it leads to positive changes in the spectrum of PL membranes.
References
Жарінов Олег Йосипович, Талаєва Тетяна Володимирівна, Ліщишина Олена Михайлівна Фібриляція передсердь адаптована клінічна настанова, заснована на доказах // — 2015.
Paulus Kirchhof Stefano Benussi, Dipak Kotecha 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS // European Heart Journal (2016) 37, 2893—2962.
Link KP (1 January 1959). «The discovery of dicumarol and its sequels». Circulation 19 (1): 97—107.
Shen G, Cui W, Zhang H Warfarin traps human vitamin К epoxide reductase in an intermediate state during electron transfer. // Nat Struct Mol Biol. 2017 Jan;24(l):69-76.
Feras Hatahet, Jessica L. Blazyk, Eugenie Martineau Altered Escherichia coli membrane protein assembly machinery allows proper membrane assembly of eukaryotic protein vitamin К epoxide reductase // Proc Natl Acad Sci USA. 2015 Dec 8; 112(49): 15184— 15189.
Cao Z, van Lith M, Mitchell LJ Membrane composition influences the activity of in vitro refolded human vitamin К epoxide reductase. // Biochemistry. 2015 Oct 27;54(42):6454-61.
Chen D, Gao Y, Nicholas J. Human herpesvirus 8 interleukin-
contributes to primary effusion lymphoma cell viability via suppression of proapoptotic cathepsin D, a cointeraction partner of vitamin К epoxide reductase complex subunit 1 variant 2. // J Virol. 2014 Jan;88(2): 1025-38.
Ponziani FR, Pompili M, Di Stasio E, Zocco MA, Gasbarrini A, Flore R Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms. // World J Gastroenterol. 2017 Feb 21;23(7):1241-1249.
Proietti M, Guiducci E, Cheli P, Lip GY Is There an Obesity Paradox for Outcomes in Atrial Fibrillation? A Systematic Review and Meta-Analysis of Non-Vitamin К Antagonist Oral Anticoagulant Trials // Stroke. 2017 Mar 6.
Hildebrandt EF, Suttie JW. Mechanism of coumarin action: sensitivity of vitamin К metabolizing enzymes of normal and warfarinresistant rat liver. // Biochemistry. 1982 May ll;21(10):2406-ll.
Montagut-Romans A, Boulven M, Jacolot M, Moebs-Sanchez S, Hascont C, Hammed A, Besse S, Lemaire M, Benoit E, Lattard V, Popowycz F Synthesis and biological evaluation of C-3 aliphatic coumarins as vitamin К antagonists. // Bioorg Med Chem Lett. 2017 Feb 11.
Gross BW, Gillio M, Rinehart CD, Lynch CA, Rogers FB Omega-3 Fatty Acid Supplementation and Warfarin: A Lethal Combination in Traumatic Brain Injury. // J Trauma Nurs. 2017 Jan/ Feb;24(l): 15-18.
Kanai S, Uto K, Honda K, Hagiwara N, Oda H. Eicosapentaenoic acid reduces warfarin-induced arterial calcification in rats. // Atherosclerosis. 2011 Mar;215(l):43-51.
De Curtis A, D Adamo MC, Amore C, Polishchuck R, Castelnuovo AD, Donati MB, Iacoviello L Experimental arterial thrombosis in genetically or diet induced hyperlipidemia in rats—role of vitamin К-dependent clotting factors and prevention by low-intensity oral anticoagulation // Thromb Haemost. 2001 Dec;86(6): 1440-8.
Cromeens DM, Rodgers GP, Minor ST. Warfarin sodium for anticoagulation of atherosclerotic miniature swine. // J Invest Surg. 1990;3(2): 141-5.
Lutomski DM, Palascak JE, Bower RH. Warfarin resistance associated with intravenous lipid administration. // JPEN J Parenter Enteral Nutr. 1987 May-Jun; 11(3):316-8.
Yeh E, Wood RD, Leeson S, Squires EJ. Effect of dietary omega-3 and omega-6 fatty acids on clotting activities of Factor V, VII and X in fatty liver haemorrhagic syndrome-susceptible laying hens. / / Br Poult Sci. 2009 May; 50(3):382-92.
Chetty N, Reavis S, Solomons HD, Pienaar N, Baynes R, Meriwether D, Atkinson PM Platelet aggregations, fatty acids, clotting factors and serum lipids in rural and urban blacks, and urban whites in South Africa. // Artery. 1988;15(5):234-49.
Tholstrup T Influence of stearic acid on hemostatic risk factors in humans. // Lipids. 2005 Dec;40(12):1229-35.
Benjamin Jenkins, Janes A. West and Albert Koulman A review of odd chain fatty acid metabolism and the role of pentadecanoic acid and heptadecanoic acid in health and disease // Molecules. — 2015. — №s20. - P. 2425-2444.
Khaw K.T., Friesen M.D., Riboli E. et all. Plasma phospholipid fatty acid concentration and incident coronary heart disease in men and women: The EPIC-norfolk prospective study. PLoS Med. 2012, 9, Re1001255.
Hodge, A.M.; English, D.R.; O’Dea, K. et all. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: Interpreting the role of linoleic acid. Am. J. Clin. Nutr. 2007, 86, 189—197.
Jason HY Wu, Rozenn N Lemaitre, Irena В King et all. Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality: The Cardiovascular Health Study // Circulation. - 2014 Oct 7. - №>130(15). - P. 1245-1253.
Giacomo Levantesi, Maria Giuseppina Silletta, and Roberto Marchioli Uses and benefits of omega-3 ethyl esters in patients with cardiovascular disease // J Multidiscip Healthc. — 2010. — №>3. C. 79— 96.
Sven О. E. Ebbesson, Venkata S. Voruganti, Paul B. Higgins et all. Fatty acids linked to cardiovascular mortality are associated with risk factors // Int J Circumpolar Health. — 2015. — №°74. — P. 10.
William S Harris, Kevin F. Kennedy, James H O’Keefe and John A. Spertus Red blood cell fatty acid levels improve GRACE score prediction of 2-yr mortality in patients with myocardial infarction // Int J Cardiol. - 2013 Sep 20. - №>168(1). - P. 53-59.
Livne A, Packham MA, Guccione MA, Mustard JF Aggregation-related association of lipid with the cytoskeleton of rabbit and human platelets prelabeled with [3H]palmitic acid. Similar effects of adenosine diphosphate- and thrombin-induced aggregation // J Clin Invest. 1988 Feb;81(2):288-99.
Fukamachi N, Watanabe Y, Kobayashi B. Inhibition of thrombin-induced platelet aggregation by myristic acid // Thromb Res. 1988 Nov 1 ;52(3):227-35.
Amanda M. Fretts, Dariush Mozaffarian, David S. Siscovick, MD, MPH, Luc Djousse, MD, DSc, Susan R. Heckbert, MD, Irena B. King, Barbara McKnight, Colleen Sitlani, Frank M. Sacks, Xiaoling Song, Nona Sotoodehnia, Donna Spiegelman, Erin R. Wallace and Rozenn N. Lemaitre Plasma Phospholipid Saturated Fatty Acids and Incident Atrial Fibrillation: The Cardiovascular Health Study // J Am Heart Assoc. - 2014 Jun. - №°3(3). - C. e000889.
Hannia Campos, Ana Baylin and Walter C. Willett 6- Linolenic acid and risk of nonfatal acute myocardial infarction // Circulation. - 2008 Jul 22. - №>118(4). - C. 339-345.
Tholstrup T, Miller GJ, Bysted A, Sandstripn В Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men. // Am J Clin Nutr. 2003 May;77(5): 1125-32.
Климов АН., Никулъчева Н.Г. Обмен липидов и липопротеидов и его нарушения. — СПб: Питер Ком, 1999. — 512 с.
Siafaka-Kapadai A, Hanahan DJ, Javors МА Oleic acid- induced Са2+ mobilization in human platelets: is oleic acid an intracellular messenger? // J Lipid Mediat Cell Signal. 1997 Mar;15(3):215-32.
Khan WA, Blobe G, Halpern A, Taylor W, Wetsel WC, Burns D, Loomis C, Hannun YA Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. // J Biol Chem. 1993 Mar 5;268(7):5063-8.
Daret D, Blin P, Larrue J Synthesis of hydroxy fatty acids from linoleic acid by human blood platelets // Prostaglandins. 1989 Aug;38(2):203-14.
Torres-Duarte AP, Vanderhoek JY Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets // Biochim Biophys Acta. 2003 Apr 7; 1640(l):69-76.
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