DETERMINATION OF PLASMA HEMOSTASIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE COMBINED WITH STAGE II HYPERTENSION BYUSING HIGHLY SPECIFIC SNAKE VENOMS

Abstract

Most clotting factors are constantly formed by the liver and are constantly used in the body. Diseases of the liver, which violate the normal synthesis of these proteins, can lead to changes in the system of hemostasis. Among liver diseases, the most common is non-alcoholic fatty liver disease (NAFLD). NAFLD is an independent risk factor for the development and progression of cardiovascular diseases (CVD). The accumulated clinical experience of the study of hypertension (HT), as the most common disease among CVD, allows us to regard high blood pressure as one of the etiological factors of thrombogenic changes in the blood. The aim of the work was to determine the state of plasma hemostasis by using coagulation tests based on highly specific snake venoms in patients with NAFLD combined with stage II HT. In patients with NAFLD Echitoxic time is prolonged, indicating a slowing of clot formation at Factor II level of the clotting. For patients with NAFLD, as an independent desease, and in combination with stage II HT, it is characteristic to suppress the coagulation process along the external pathway of blood coagulation, which is indicated by the prolongation time of the Lebetox test. The combined NAFLD and HT accelerates the formation of thrombus in the last phase of clot formation, at the stage of converting the fibrinogen molecule to fibrin, which, against the background of an prolonged Lebetox test, indicates possible coagulopathy of consumption in the early stages of blood clotting to the formation of a prothrombin complex.