DIAGNOSTIC AND THERAPEUTIC VALUES OF AMINO ACID COMPOSITION OF BLOOD AND AMINO ACID INDICES AS MARKERS OF ARRHYTMIAS OF ISCHEAMIC GENESIS AND CARDIOVASCULAR RISK IN PATIENTS WITH STABLE ISCHEAMIC HEART DISEASE ON THE BACKGROUND OF DIABETES MELLITUS TYPE
Abstract
The purpose of the study was to determine the diagnostic value of the amino acid composition of blood (ACC) and its indices as markers of cardiac rhythm disturbances (СRD) and cardiovascular risk (CVR) in patients with stable coronary heart disease (CHD) in patients with type 2 diabetes mellitus (DM2) . Object and methods of investigation The data of examination of 51 patients with stable ischemic heart disease in the background of CD2 (30 men and 21 women, median ages -64, 2 years) and 22 patients with stable coronary heart disease without violations of carbohydrate metabolism were analyzed. 20 amino acids (AMC) and the relationships between them were determined, in which AMCs were combined by a competitive mechanism of transport into the cell. According to the results of holter ECG monitoring, patients with comorbid pathology were divided into 2 groups: with and without arrhythmias of ischemic genesis (AIG) of high grades.
Results The Tau / Ala and Fen + Tyr / Met indices have high specificity (Sp) and positive predictive value (PPV) (93.9 and 95.1 and 93.9 and 95.1, respectively) at low sensitivity (Se ) and negative predictive value (NPV). The Tau and BCCA indices showed low Sp and PPV at high Se and NPV (89.9 and 86.7 and 84.6 and 86.5, respectively). The statistically significant correlation between the ASA indices and the parameters characterizing lipid (LO) and carbohydrate metabolism (VO), SDP, and cardiovascular risk (SSR) on the SMART scale (SMART RISK) were found.
Conclusions Since none of the specified indicators demonstrated simultaneously high specificity and sensitivity to AIG, and correlation relationships with lipid and carbohydrate metabolism and AIG did not show a high and moderate strength of communication in all parameters, the indices should be applied in accordance with the research stage: Tau and ARCs are most suitable for screening purposes, Tau / Ala and Phen + Tyr / Meth are more suitable for the purpose of therapy and as a control of treatment.
References
BouletMM., Chevner G., Grenier LaroucheT., PelletierM., Nadeau M., Scarpa J. et al Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk. Am J Physiol20J5; 309E736-46
Bousquet P, Feldman J., Bloch R. and Schwartz, J. The central cardiovascular effects of taurine. Eur. J. Pharmacol, 98:269-273, 1984.
Carsten W. Mechanisms of sudden cardiac death Israel 2014 Jan; 66(Suppl 1): S10-S17.
Cavallaro N.L., Garry J., ShiX., Gerszten R.E., Anderson E. J., Walford G. A. A pilot, short-term dietary manipulation of branched chain amino acids has modest influence on fasting levels of branched chain amino acids. Food Nutr Res 2016', 6028592.
EstruchR., RosE., Salas-SalvadoJ., CovasM.I., CorellaD., ArosF., et al Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013',368'.1279-90.
Hernandez J., Artillo S., Serrano M. I. and Serrano J. S. Further evidence of the antiarrhythmic efficacy of taurine in the rat heart. Res. Commun. Chem. Patho. Pharma., 43(2):343-346, 1984
Iwasaki M., IshiharaJ., Takachi R., Todoriki H., Yamamoto H, Miyano H., Validity of a self-administered food-frequency questionnaire for assessing amino acid intake in Japan: comparison with intake from 4-day weighed dietary records and plasma levels. J Epidemiol 201&J26-.36-44.
Finley R.J., Inculet R.I. et al: Major operative trauma increases peripheral amino acid release during the steady-state infusion of total parenteral nutrition in man. Surgery, 99(4):491-500 1986Apr.
Franceschi and Campisi. Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sei Med Sei. 69(S1):S4-S9 (2014).
MannaP., Das J., Sil P,Role of sulfur containing amino acids as an adjuvant therapy in the prevention of diabetes and its associated complications/Curr Diabetes/2013, May, 9(3) 237-48
Martun-Timyn I., Sevillano-Collantes C, Segura-Galindo A., Del Cacizo-Gymez F.J. Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength? World J Diabetes 2014;5:444-470
Mayhew A.J., de Souza R.J., MeyreD., Anand S.S., MenteAA. systematic review and meta-analysis of nut consumption and incident risk of CVD and all-cause mortality. Br J Nutr 2O16',115212-2
Newgard C. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab 2O12',156O6-14.
Ruiz-CanelaM., ToledoE., Clish C.B., HrubyA., LiangL., Salas- Salvady J., Plasma branched-chain amino acids and incident cardiovascular disease in the PREDIMED trial. Clin Chem 2016',62582-92.
Sebring L. A. and Huxtable R. J. Cardiovascular actions of taurine. In: Sulfur Amino Acids: Biochemical & Clinical Aspects, 1983
WessbergP., Hedner T, HednerJ. andJonasonJ. Effects of taurine and a taurine antagonist on some respiratory and cardiovascular parameters. LifeSci., 33:1649-1655, 1983.
WurtzP., HavulinnaA.S., SoininenP., TynkkynenT, Prieto- MerinoD., Tillin T. et al. Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts. Circulation 2015', 131 774-85.
XuAmeja, Tappia et al. The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol. 13(2):57-65 (2008).
Y. Yin, X. Wen, Y. Wu, Y. Kang, and J. Lou, “Inhibition of sodium current by taurine magnesium coordination compound prevents cesium chloride-induced arrhythmias,” Biological Trace Element Research, vol. 146, no. 2, pp. 192—198, 2012.
www.who.int/gho/publications/world_health_statistics/2016/en/
This work is licensed under a Creative Commons Attribution 4.0 International License.
ISSN 
ISSN 
