Peculiarities of regeneration of an experimental femur fracture in rats with intramedullary fixation with carbon-carbon composite material implants
Abstract
the issue of finding modern bioinert materials for use in surgical orthopedics and traumatology, as well as other medical fields related to the surgical treatment of diseases of the musculoskeletal system, is the most urgent today. The aim of the study was to establish the features of the course of regeneration of a femur fracture in rats with intramedullary fixation of fragments with a carbon-carbon composite material. The femur of 12 Wistar rats was studied in the work. Six rats - with simulated transverse diaphyseal fracture and intramedullary fixation with carbon-carbon composite material and six rats - with simulated transverse diaphyseal fracture and intramedullary fixation with medical steel. The last one were used as a comparison group. Histological sections prepared according to standard methods for inspection microscopy were stained with hematoxylin and eosin. To study revascularization processes, an immunohistochemical reaction with CD-34 antibodies was performed. As a result of the study, it was established that in animals with a simulated complete transverse diaphyseal fracture of the femur and intramedullary fixation with implants made of carbon-carbon composite material in the bone regenerate, the relative area of CD-34+ vascular endothelial cells probably increases compared to the group of animals in which fixation was performed using medical stainless steel. Thus, the use of carbon-carbon composite material reveals an angiogenic effect in bone regeneration, which accelerates the rate of repair and remodeling of fractures.
References
Hak, D.J., Mauffrey, C., Seligson, D., & Lindeque, B.G. (2014). Use of carbon-fiber-reinforced composite implants in orthopedic surgery. Orthopedics, 37 12, 825-30 .
Kang, M. S., Lee, J. H., Hong, S. W., Lee, J. H., & Han, D. (2021b). Nanocomposites for enhanced osseointegration of dental and orthopedic implants revisited: Surface functionalization by carbon nanomaterial coatings. Journal of Composites Science, 5(1), 23. https://doi.org/10.3390/jcs5010023
Pesare, E., Meschini, C., Caredda, M., Messina, F., Rovere, G., Solarino, G., & Ziranu, A. (2024). Carbon vs. Titanium Nails in the Treatment of Impending and Pathological Fractures: A Literature Review. Journal of Clinical Medicine, 13.
Wright, Z.M., Arnold, A.M., Holt, B.D. et al. (2019). Functional Graphenic Materials, Graphene Oxide, and Graphene as Scaffolds for Bone Regeneration. Regen. Eng. Transl. Med.5, 190–209 https://doi.org/10.1007/s40883-018-0081-z
Yeung, C. M., Bhashyam, A. R., Patel, S. S., Ortiz-Cruz, E., & Lozano-Calderón, S. A. (2022). Carbon fiber implants in orthopaedic oncology. Journal of Clinical Medicine, 11(17), 4959. https://doi.org/10.3390/jcm11174959
Zhao, F., Zhang, L., Guo, Y., Sheng, H., Zhang, P., Zhang, Y., Li, Q., Yang, H., & Mikhalovsky, S. V. (2021). Mechanically strong and bioactive carbon fiber-SiC nanowire-hydroxyapatite-pyrolytic carbon composites for bone implant application. Ceramics International, 47(3), 3389–3400. https://doi.org/10.1016/j.ceramint.2020.09.184
Чорний, В. В. (2023). Вуглицеві композитні матеріали як імплантати для ортопедії і травматології (огляд літератури). SWorldJournal, (22 Part 2), 77-83. https://doi.org/10.30888/2663-5712.2023-22-02-040
This work is licensed under a Creative Commons Attribution 4.0 International License.
ISSN 
ISSN 
